N-terminal alkylated derivatives of [D-Pro10]dynorphin A-(1-11) are highly selective for kappa-opioid receptors

J Med Chem. 1992 Nov 27;35(24):4638-9. doi: 10.1021/jm00102a019.
No abstract available

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alkylation
  • Amino Acid Sequence
  • Animals
  • Cerebellum / metabolism
  • Dynorphins / analogs & derivatives*
  • Dynorphins / chemistry
  • Dynorphins / metabolism
  • Dynorphins / pharmacology
  • Guinea Pigs
  • Ileum / drug effects
  • Ileum / physiology
  • Molecular Sequence Data
  • Peptide Fragments / chemical synthesis
  • Peptide Fragments / chemistry*
  • Peptide Fragments / metabolism
  • Peptide Fragments / pharmacology
  • Receptors, Opioid, kappa / metabolism*

Substances

  • Peptide Fragments
  • Receptors, Opioid, kappa
  • Dynorphins
  • dynorphin (1-11), Pro(10)-